Global Medicare · Endometrial Research
RegenEndo
Study 03-REGEN-AR
A prospective observational study comparing endometrial development and reproductive parameters associated with two autologous PRP preparation approaches used within routine clinical care at IVF Baden-Baden.
Participation in the study is separate from clinical care. Treatment selection and final research eligibility remain with the authorised medical and research teams.
Study overview
RegenEndo at a glance.
03-REGEN-AR is the endometrial observational study conducted at IVF Baden-Baden under the direction of Prof. Dr. med. Wolfgang Küpker.
thickness primary comparison parameter
Primary research question
Does endometrial development differ between patients receiving Standard-PRP and IAS within routine clinical care?
The principal comparison focuses on endometrial development, particularly endometrial thickness, after the two autologous preparation approaches.
Study participation does not determine which preparation is used. That decision belongs to clinical care.
Study design
Designed to observe routine endometrial clinical care.
RegenEndo prospectively documents defined endometrial and reproductive parameters in patients receiving Standard-PRP or IAS as part of routine clinical care.
Study information is documented forward in time.
The study observes clinical care rather than assigning treatment.
The study is conducted at IVF Baden-Baden.
Standard-PRP and IAS are not randomly allocated by the study.
Study population
A diverse endometrial and implantation-related population.
The general study population includes women aged 20 to 50 years with endometrial or implantation-related clinical profiles relevant to the protocol.
These are general population profiles. They do not constitute an online eligibility checklist.
Observation pathway
From clinical assessment to prospective endometrial observation.
The study follows predefined endometrial parameters within the routine clinical pathway while keeping treatment decisions independent from research participation.
Relevant endometrial and reproductive information is documented.
The preparation approach is selected independently by the clinical team.
Defined ultrasound and endometrial parameters are documented prospectively.
Implantation and reproductive outcomes can be documented where applicable.
Study parameters
Endometrial development is observed in multiple dimensions.
Thickness is the primary comparison parameter, accompanied by additional morphological, volumetric, vascular and reproductive information.
Endometrial thickness is the central primary comparison parameter.
Three-dimensional and morphological information forms part of the broader assessment.
Endometrial and subendometrial vascularisation indices are documented.
Implantation, pregnancy and other reproductive outcomes may be documented when applicable.
These are study parameters. This website does not use individual measurements to predict implantation, pregnancy or treatment success.
Autologous preparations
Two clinical preparation approaches. One observational comparison.
Standard-PRP and IAS are both autologous preparations derived from the patient’s own blood.
IAS includes additional processing of naturally occurring components from fractions of the same autologous sample.
The clinical preparation is selected before and independently of research participation.
RegenEndo does not establish that IAS is clinically superior to Standard-PRP. IAS should not be described as purified exosome therapy.
Research governance
Conducted at IVF Baden-Baden.
RegenEndo is conducted under the direction of Prof. Dr. med. Wolfgang Küpker.
Important research information
Research information should not be confused with clinical eligibility.
Does this page confirm whether I am eligible for RegenEndo?
Does RegenEndo decide whether I receive Standard-PRP or IAS?
Does a specific endometrial thickness automatically determine eligibility?
Does participation guarantee greater endometrial thickness or pregnancy?
Can I enrol directly through Global Medicare?
Your next step
Interested in discussing your endometrial situation?
The Endometrial Program is the patient pathway for initial orientation, specialist assessment and coordination. Research participation, when applicable, is considered separately by the authorised medical and research teams.